Trusted Rare Disease Intelligence
Connecting clinical data, real-time news, policy tracking, and patient resources across 15,964+ rare diseases — grounded in open science.
Why This Matters
For patients and families facing a rare disease diagnosis, finding reliable information is exhausting. Generic health sites offer surface-level overviews. Medical journals are locked behind paywalls and written for specialists. The information that exists is scattered across dozens of sources, often contradictory, frequently outdated.
Meanwhile, the people who know the most about living with these conditions - patients, caregivers, and the dedicated PAGs who support them - have no central place to share their hard-won knowledge.
We're changing that.
What Kisho Does
Four connected intelligence layers — updated daily, grounded in open science.
Disease Intelligence
Patient-ready reports across 15,964+ rare diseases, synthesized from clinical databases and validated through a multi-stage QC pipeline. Gene associations, phenotypes, prevalence data, FDA-approved treatments, and orphan drug designations — all in plain language.
Browse DiseasesNews & Pipeline Monitoring
AI-curated news from 25+ authoritative sources — FDA, NIH, BioSpace, STAT News, PubMed, SEC filings, and more. Every article is classified by category, scored for significance, and auto-linked to the diseases it affects. Daily briefings and a weekly newsletter keep you current.
Read Latest NewsPolicy Tracking
50-state legislative monitoring with AI classification across 9 NORD policy categories. Bills are scored for rare disease relevance, linked to affected diseases, and tracked from introduction through enactment. Know what's moving before it moves.
Track PolicyPatient & Community Resources
A verified directory of patient advocacy groups with persistent RDCP identifiers, patient assistance programs aggregated from NORD, PAN Foundation, Good Days, and HealthWell, and community-contributed stories and feedback.
Find SupportBuilt for the Rare Disease Ecosystem
One platform, four doors. Each audience enters through the message that speaks to them.
Patients & Families
Understand your rare disease — clearly, completely, in one place.
- Plain-language disease reports
- Patient assistance programs
- Find support organizations
PAG Leaders
Everything your disease community needs — in one place.
- Disease-specific content widgets
- News intelligence for your community
- Newsletter tools & team access
Enterprise & Biotech
Rare disease intelligence via API. 15,964 diseases. Real-time.
- Structured REST API with 18+ endpoints
- AI-generated, QC-validated content
- Deploy in days, not months
Policy Advocates
Track the legislation that affects your patients, across 50 states.
- 50-state policy bill monitoring
- AI-classified by policy category
- Disease-linked legislative tracking
What We Stand For
Four principles guide everything we build.
Free Knowledge for All
Every disease report on Kisho is free to read, share, and print. No paywalls. No subscriptions. Information about your health should never be locked behind a credit card.
Radical Transparency
Every edit creates an audit-ready provenance record. See exactly who changed what, when, and why. Every source cited. Every contributor credited. Complete version history for clinicians, researchers, and regulators.
AI-Drafted, Expert-Validated
AI synthesizes medical literature into patient-friendly reports. But AI only drafts. Named Expert Stewards validate every report, standing behind their validation. You always know the validation status.
Community-Built Accuracy
The best disease information comes from those who live it. Patients, caregivers, and medical experts contribute their knowledge, creating reports that are both scientifically sound and deeply informed by real experience.
How It Works
Intelligence that starts with data and ends with trust.
We Aggregate
Every day, Kisho pulls from FDA, NIH, ClinicalTrials.gov, MONDO, HPO, Orphanet, PubMed, Congress.gov, and 20+ news sources. Structured APIs, RSS feeds, and discovery search ensure nothing gets missed.
AI Classifies & Connects
AI synthesizes disease reports, classifies news by category and significance, tags articles to the diseases they affect, and scores policy bills for rare disease relevance. Every output goes through a multi-stage QC pipeline.
Experts & Community Validate
Named Expert Stewards validate disease reports. Community members contribute lived experience. Every edit creates an audit trail. You always know the validation status of what you’re reading.
How We Build Clinical-Grade Trust
Kisho isn't just a health website. It's a governed knowledge system designed for clinical scrutiny, research use, and regulatory review.
5-Stage Validation
Every report displays its trust level: AI Draft → Community Reviewed → Expert Validated. You always know exactly how verified the information is.
Named Stewards
Unlike anonymous wikis, our reports have named owners. Verified professionals claim pages, review changes, and stand behind their work.
Complete Provenance
Every change creates an audit record: what changed, who changed it, why, and what sources they cited. Built for clinician and regulator scrutiny.
Safety-First Language
Our AI preserves medical uncertainty: "may be associated with," "research suggests." We never claim certainty we can't prove.
Translation Trust
Translations inherit validation status from source. When sources change, translations are flagged for review. The original is always authoritative.
Learn More
Have questions about our validation process, expert stewards, or how we handle AI-generated content?
Grounded in Open Science
Every claim on Kisho traces back to an authoritative source. We synthesize across these foundations to build a unified intelligence layer.
MONDO Ontology
Disease classification backbone — 23,529+ diseases
HPO
Clinical phenotypes with frequency data
Orphanet
Prevalence estimates and epidemiological data
ClinicalTrials.gov
Active and total trial counts per disease
FDA
Orphan drug designations and approved treatments
NIH / PubMed
Research publications and citation enrichment
HGNC
Gene symbol validation — 44,748 approved symbols
Congress.gov
Federal legislative tracking
25+ News Sources
BioSpace, STAT, Fierce Pharma, FDA alerts, and more
Build with KISHO
Building a digital health product? Access 15,964+ validated disease reports via API. Start free with 1,000 requests/month — no credit card required. Our content infrastructure powers patient portals, EHRs, and digital health applications.
Join the Movement
Whether you're a patient searching for answers, a PAG leader serving your community, an enterprise building digital health products, or a policy advocate tracking legislation — there's a place for you at Kisho.
Want to partner with us? Learn about partnership opportunities →