Currarino triad

Currarino syndrome is a rare congenital condition that is defined by a specific triad of abnormalities. People with this condition typically have an anorectal malformation, which often presents as anal stenosis, a presacral mass such as an anterior sacral meningocele or a teratoma, and anomalies of the sacral region. This combination of features distinguishes Currarino syndrome from other congenital conditions and often leads to early identification in childhood. The condition is called a syndrome because it involves a group of findings that appear together. The presence of sacral anomalies can include either partial or complete absence of parts of the sacrum and coccyx, or deformities of the sacral vertebrae, which are key aspects that define this triad. Recognizing these features is important in understanding and managing the condition.

The most common symptom seen in Currarino syndrome is an anorectal malformation, usually in the form of anal stenosis, which may lead to difficulties with bowel movements. In addition, the presacral mass, which might be an anterior sacral meningocele or a teratoma, can cause pressure-related symptoms. The sacral anomalies, such as partial absence or deformity of the sacrum and coccyx, are a key sign of the condition and may be noticed on imaging studies. These combined features form the main pattern of symptoms in people with Currarino syndrome.

Currarino syndrome is a congenital condition that occurs during fetal development. It has been linked to changes in the MNX1 gene, which plays an important role in the formation of the structures that are affected in this syndrome. While the exact cause can be complex and vary among people, the involvement of this gene suggests that genetics plays a significant role in the development of the condition.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about research is currently limited for this condition.