Crane-Heise syndrome

Crane-Heise syndrome is a very rare condition that affects the development of bones and the face. People with this syndrome usually have a poorly mineralized calvarium (the skull cap), which may lead to a softer or less robust skull structure. In addition, they often show facial dysmorphism, meaning that there are noticeable differences in the shape and structure of the face compared to typical development. Moreover, the syndrome is marked by vertebral abnormalities and the absence of clavicles (collar bones). Some reports and synonymous descriptions also mention features such as cleft lip and/or cleft palate and talipes equinovarus (clubfoot). These features can vary among individuals, and because this syndrome is so rare, the full range of its presentation is still being understood. The information currently available comes from clinical definitions and descriptors documented in trusted medical sources.

Common signs of Crane-Heise syndrome include a poorly mineralized skull and unique facial features. People with this condition may also have vertebral (spine) abnormalities and missing collar bones. Some descriptions note the presence of cleft lip or palate and talipes equinovarus (clubfoot). It is important to note that the symptoms can vary between individuals, and not everyone will show all the features mentioned.

Information about causes is currently limited for this condition.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about research is currently limited for this condition.