Dubin-Johnson syndrome

Dubin-Johnson syndrome is a benign, inherited liver disorder. It is characterized by a chronic increase in mainly conjugated bilirubin, a substance produced during the normal breakdown of red blood cells. This buildup sometimes gives people a slight yellowing of the skin or eyes, a condition known as jaundice. A unique feature of this condition is the deposition of black-brown pigment in the liver cells, which is seen under a microscope. Although the liver shows these distinct changes, the condition is considered non-progressive and generally does not lead to severe liver problems. Information from sources such as the DEFINITION and databases like OMIM, Orphanet, and GARD helps underline these points.

The main symptom of Dubin-Johnson syndrome is persistent increase in conjugated bilirubin levels which may cause mild jaundice, or a yellowing of the skin and eyes. In many cases, people with this condition do not experience severe or painful symptoms.

Dubin-Johnson syndrome is an inherited condition. It is linked to changes in the ABCC2 gene, which plays a role in processing bilirubin in the liver. This genetic link is a key factor in why this condition occurs in families.

Information about treatment is currently limited for this condition.

Dubin-Johnson syndrome is generally considered to be benign. People with this condition usually have a stable outlook and can live normal lives without severe complications related to the liver disorder.

Information about research is currently limited for this condition.