VIPoma

VIPoma is an extremely rare type of pancreatic neuroendocrine tumor that secretes vasoactive intestinal polypeptide (VIP). This secretion leads to a pattern of symptoms often described as watery diarrhea, hypokalemia (low potassium levels), and achlorhydria (low stomach acid), which is known as WDHA syndrome. This condition is also sometimes known by other names such as pancreatic cholera and Verner-Morrison syndrome. It is primarily a pancreatic disorder, and the symptoms arise from the hormone imbalances caused by the tumor. Because VIPoma is rare, many aspects of the condition are still under study.

People with this condition often experience severe watery diarrhea, which can lead to dehydration. They may also have hypokalemia, a condition where potassium levels in the blood are low, and achlorhydria or hypochlorhydria, meaning there is little or no acid in the stomach. This combination of symptoms is known as WDHA syndrome.

VIPoma arises from neuroendocrine cells in the pancreas that begin to grow abnormally and secrete high levels of VIP. Information about the specific causes, genetic factors, and risk factors for developing this tumor is currently limited for this condition.

Treatment for VIPoma often involves managing the symptoms and addressing the tumor directly, typically through surgery or other interventions. However, detailed treatment options and management approaches are limited in the available information.

The outlook for people with VIPoma can vary depending on the size of the tumor, its spread, and response to treatment. Information about long-term prognosis and quality of life considerations is currently limited for this condition.

Current research on VIPoma aims to better understand its biological behavior and to develop more effective treatment strategies. However, detailed and specific research data about this condition is limited.