adult pure red cell aplasia

Adult pure red cell aplasia is a rare acquired form of aplastic anemia that affects the production of red blood cells. In people with this condition, the bone marrow shows an almost complete absence of erythroblasts (red blood cell precursors) while the production of white cells and platelets remains normal. This condition is characterized by a severe normocytic anemia, a low reticulocyte count, and high levels of serum ferritin and transferrin saturation. Because the condition is acquired, it develops later in life and is not linked to inherited genetic causes. The presentation of severe anemia usually leads to noticeable symptoms, and the condition is identified through blood tests and bone marrow evaluation. It is also known by several other names, including acquired PRCA, idiopathic pure red cell aplasia, and pure red-cell aplasia of adults.

The most common signs in people with adult pure red cell aplasia are those related to severe anemia. These include fatigue, lethargy, pallor (pale skin), and shortness of breath during physical activity. Importantly, these symptoms occur without the presence of bleeding or hemorrhagic issues.

Adult pure red cell aplasia is an acquired condition, meaning it develops during a person’s life rather than being inherited. There is limited information about the specific causes, genetic factors, and risk factors associated with this condition.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research and future directions is currently limited for this condition.