HAVCR2-related cancer predisposition

HAVCR2-related cancer predisposition is a hereditary condition caused by changes in the HAVCR2 gene. People with this condition have a higher chance of developing specific types of illnesses, namely subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and hemophagocytic lymphohistiocytosis (HLH). This means that changes in this gene can make a person more likely to experience problems with their immune system that may lead to cancer or severe immune responses. Affected individuals may notice several small lumps under the skin and symptoms that are sometimes called systemic B symptoms. These signs can include general feelings of being unwell. The condition is rare, and the way it affects people can vary. Ongoing research is expected to further clarify the full picture of this genetic change and how it can trigger these diseases.

People with this condition often show multiple subcutaneous nodules, which are small lumps under the skin. They may also experience systemic B symptoms, which is a term used to describe general signs of illness. Information about the full range of symptoms is currently limited for this condition.

This condition is caused by variations in the HAVCR2 gene. These changes in the gene can make people more likely to develop subcutaneous panniculitis-like T-cell lymphoma and/or hemophagocytic lymphohistiocytosis. The condition is inherited, meaning that these genetic changes run in families.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research and future directions is currently limited for this condition.