WT limb-blood syndrome

WT limb-blood syndrome is a rare condition that affects both the blood and the limbs. People with this condition often develop blood abnormalities such as Fanconi anemia, leukemia, or lymphoma during childhood. In addition, they may have various limb and hand differences including bifid or underdeveloped (hypoplastic) thumbs, fused fingers (cutaneous syndactyly), and issues with the bones in the forearm, such as ulnar and radial defects. The condition is inherited in an autosomal dominant pattern, meaning a change in just one copy of the gene in each cell can cause the disorder. It has been documented in several families, which helps researchers understand its genetic transmission. Additional details may emerge as further studies are conducted.

People with WT limb-blood syndrome may experience blood problems like Fanconi anemia, leukemia, or lymphoma, and limb abnormalities. These limb differences can include underdeveloped or split thumbs, webbing or fusion of the fingers, and defects in the forearm bones.

WT limb-blood syndrome is passed down in an autosomal dominant manner. This means that a change in one copy of the relevant gene may lead to the condition. Information about specific gene mutations is not provided.

Information about treatment options and management approaches is currently limited for this condition.

Information about the outlook and quality of life considerations is currently limited for this condition.

Information about current research and future directions is currently limited for this condition.