Hallermann-Streiff syndrome

Hallermann-Streiff syndrome is a rare genetic condition that mainly affects the head and face. It is marked by a bird-like appearance with a beak-shaped nose, a small lower jaw (hypoplastic mandible), and a head shape that includes a broad forehead (frontal bossing). People with this condition may also have dental challenges, skin changes, and eye problems. Besides these facial features, individuals with Hallermann-Streiff syndrome can have other physical traits, such as a short stature, hair differences, and various eye issues including congenital cataracts and small eyes (microphthalmia). Intellectual challenges are noted in some cases, although the severity can vary. The condition impacts several parts of the body but is centered around distinct craniofacial abnormalities.

Common signs and symptoms include a bird-like facial appearance, a beak-shaped nose, and a small jaw. Other features include a head shape with a prominent forehead, dental abnormalities (such as missing teeth, extra teeth, or enamel problems), eye disorders like congenital cataracts and ptosis, and skin changes such as thinning and telangiectasia. Short stature and hair differences are also reported.

Hallermann-Streiff syndrome is considered a genetic disorder. Although it is inherited, no specific gene has been identified as the underlying cause according to the available information.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition. The quality of life and outlook may vary, especially since some individuals may experience intellectual challenges, while others do not.

Information about research is currently limited for this condition.