cold-induced sweating syndrome

Cold-induced sweating syndrome, also known as CISS or Sohar-Crisponi syndrome, is a condition in which exposure to cold temperatures triggers profuse sweating on the chest, face, arms, and trunk. It is classified by a distinct abnormal response to ambient cold rather than typical thermoregulation. Given its description, the condition appears to affect individuals sporadically, and its occurrence is extremely rare, affecting fewer than 1 in 1,000,000 people. Current understanding is based primarily on clinical observations, and the genetic underpinnings remain under investigation.

The hallmark clinical feature of cold-induced sweating syndrome is excessive sweating in response to cold exposure, specifically involving the chest, face, arms, and trunk. This profuse sweating may be surprising and distressing to those affected, leading to difficulties in managing day-to-day activities during cold weather. Not all individuals experience the condition in exactly the same way, and severity may vary considerably between cases.

At present, the precise genetic basis of cold-induced sweating syndrome is under investigation. There is no definitive genetic marker or clearly established inheritance pattern documented in the available literature. The condition is thought to result from complex factors, and further research is needed to understand potential genetic and environmental contributions. In the absence of identifiable causative genes, families are encouraged to discuss any concerns with genetics specialists.

Currently, management of cold-induced sweating syndrome focuses on supportive care and symptom management rather than on any specific approved treatments. Strategies may include minimizing exposure to cold environments, using protective clothing to maintain body warmth, and employing environmental adjustments to reduce symptoms. Treatment is tailored to the individual and typically involves collaboration with a multidisciplinary team. Patients are advised to discuss personalized management plans with their healthcare team.

Outcomes for individuals with cold-induced sweating syndrome vary, and the clinical course is generally determined by how effectively symptoms are managed. With current standards of care, many individuals learn to adapt to the condition and minimize the impact of cold-induced symptoms on daily life. Outcomes described in medical literature continue to evolve as standards of care improve, and it is important to recognize that severity and progression differ between individuals. Families often find it helpful to connect with specialists experienced in managing temperature-sensitive conditions, and genetic counseling can provide further guidance on long-term care and family planning.