Olmsted syndrome

Olmsted syndrome is a hereditary condition that affects the skin, particularly the palms of the hands and the soles of the feet. It is characterized by a combination of a severe thickening (keratoderma) that can lead to mutilation and the appearance of keratotic plaques around body openings (periorificial areas). This condition is known by several names, including mutilating palmoplantar hyperkeratosis with periorificial keratotic plaques and palmoplantar and periorificial keratoderma. The description highlights both the palmoplantar and periorificial involvement, making this a unique form of keratoderma.

People with Olmsted syndrome typically experience thickened skin on their palms and soles that can become severe and mutilating. They also develop keratotic plaques around areas such as the mouth and other body openings. These skin changes can cause discomfort and affect daily activities.

Olmsted syndrome is a hereditary condition, meaning it runs in families. The exact genetic cause is not clear from the available information, and specific genes have not been identified as playing a role.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research and future directions is currently limited for this condition.