The Department of Health and Human Services is reopening the public comment period for its proposed rulemaking on nondiscrimination based on disability. This NPRM aims to clarify the exclusion of certain gender identity disorders from discrimination definitions, addressing ambiguities in federal financial assistance programs.

The Department of Health and Human Services has released an updated list of certified laboratories and Instrumented Initial Testing Facilities for urine and oral fluid drug testing. This ensures compliance with the Mandatory Guidelines for Federal Workplace Drug Testing Programs.

NIOSH seeks public input on priority topics for firefighter safety and health, aiming to enhance research and services that address emerging hazards in the fire service. This initiative reflects ongoing efforts to improve occupational safety standards for firefighters.

A recent study explores venous overload choroidopathy alongside chronic central serous chorioretinopathy and uveal effusion syndrome. This research contributes to the understanding of complex ocular conditions and their interrelations.

Regenxbio's RGX-111, a gene therapy for Hurler syndrome, faces uncertainty after a cancer case was reported in its Phase 1/2 trial. This therapy aims to deliver a gene to central nervous system cells to produce the deficient enzyme, addressing the challenges of enzyme replacement therapy.

The FDA has initiated the PreCheck pilot program to enhance domestic pharmaceutical manufacturing, inviting companies to submit participation requests. This program aims to streamline regulatory processes and improve supply chain resilience.

A new expert consensus from China outlines the diagnosis and treatment protocols for Becker muscular dystrophy, aiming to standardize care for this rare condition. This consensus may enhance clinical practices and improve patient outcomes.

A recent case study highlights pseudohyponatremia in a patient with severe liver disease, shedding light on the complexities of electrolyte imbalances in this population. This finding may influence clinical approaches to managing sodium levels in patients with liver conditions.

Recent research highlights that aberrant protein S-nitrosylation can replicate the effects of rare genetic mutations in neurodegenerative diseases. This discovery may open new avenues for understanding disease mechanisms and developing targeted therapies.

A study identifies a novel PORCN variant (c.1093C>T, p.Arg365Trp) in a 12-year-old girl with Goltz-Gorlin syndrome. This discovery adds to the understanding of genetic mutations associated with this rare condition.

A case report details a rare surgical complication involving an iatrogenic left circumflex artery aneurysm that fistulized to the coronary sinus after mitral valve replacement. This highlights the potential risks associated with cardiac surgeries.

A recent retrospective cohort study investigates the impact of hydroxychloroquine on mortality and cardiovascular outcomes in systemic sclerosis. The findings contribute to understanding treatment efficacy in this rare disease.

A new case report on disseminated peritoneal leiomyomatosis provides insights into this rare condition. The findings contribute to the understanding of its clinical presentation and management.

A recent study discusses the implementation of patient retreats during dose escalation phases of Phase I clinical trials for rare diseases. This approach aims to enhance patient engagement and optimize trial outcomes.

A new study explores the selection for function in complex distributed pathological systems, providing insights into disease mechanisms. This research could inform future therapeutic strategies for rare diseases.

A case report details a 52-year-old male diagnosed with mixed adenoneuroendocrine carcinoma of the stomach following total D2 gastrectomy. This case contributes to the understanding of MANEC, a rare and complex tumor type.

A case report details an idiopathic renal infarct in a healthy adult with an accessory renal artery, contributing to the understanding of renal vascular anomalies. This case highlights the potential for unexpected renal complications in otherwise healthy individuals.