xeroderma pigmentosum

Xeroderma pigmentosum (XP) is a rare genetic skin disorder that causes extreme sensitivity to sunlight. People with this condition have skin and eye changes when exposed to ultraviolet (UV) light. Over time, these changes can lead to multiple skin cancers. XP is divided into 8 different groups, with classical forms (XPA to XPG) and an XP variant, based on which gene is affected. This condition is seen as a genodermatosis, meaning it is related to the skin and is inherited. It affects the way the body repairs damage caused by UV light, which can result in serious skin problems. Information about the complete range of symptoms and severity can vary among those with XP, making careful management important.

Common symptoms of xeroderma pigmentosum include an extreme sensitivity to sunlight and UV radiation. This sensitivity can cause early and severe sunburns, skin damage, and a higher risk of developing skin cancers. The eyes can also be affected by UV light, potentially leading to vision problems over time.

Xeroderma pigmentosum is caused by changes in genes that are important for repairing DNA damage from UV light. These genetic changes make it very difficult for the body to fix the damage caused by the sun, which leads to the symptoms seen in this condition. The disorder is subdivided into classical XP (XPA to XPG) and an XP variant, depending on which gene is affected.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about research is currently limited for this condition.