ADULT syndrome

ADULT syndrome is a rare genetic condition that affects the skin, nails, teeth, and other parts of the body. It is classified as an ectodermal dysplasia syndrome and is known for its unique combination of physical findings such as cutaneous freckling, dental abnormalities (hypodontia), and lacrimal duct anomalies. People with ADULT syndrome may also experience limb differences like ectrodactyly (missing or split fingers or toes) and syndactyly (fusion of digits), as well as underdeveloped breasts (mammary hypoplasia), thin hair (hypotrichosis), and nail irregularities (onychodysplasia). These characteristics help in recognizing the condition as described in trusted sources.

Common signs of ADULT syndrome include ectrodactyly, syndactyly, and distinctive skin findings such as excessive freckling. Other symptoms include mammary hypoplasia, hypodontia (fewer teeth than usual), anomalies in the lacrimal ducts, hypotrichosis (sparse hair), and onychodysplasia (abnormal nail development).

ADULT syndrome is related to changes in the TP63 gene. This gene plays an important role in the development of various tissues, and disturbances can lead to the features seen in this condition. Detailed information about risk factors beyond this genetic link is limited.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research and future directions is currently limited for this condition.