Bruton-type agammaglobulinemia

Bruton-type agammaglobulinemia, also known as X-linked agammaglobulinemia (XLA), is an inherited immunodeficiency disorder. It is called X-linked because the gene affected is located on the X chromosome. This condition primarily affects males and is characterized by a low level of antibodies, which makes it harder for the body to fight bacterial infections. The recurrent bacterial infections seen in affected individuals typically begin during infancy. The disorder is one of the many examples of isolated agammaglobulinemia, where the immune system is specifically weakened due to the inability to produce sufficient antibodies.

People with this condition often experience recurrent bacterial infections, which usually start in infancy. These infections occur because of the reduced ability to produce antibodies, an essential part of the immune response.

Bruton-type agammaglobulinemia is caused by mutations in the BTK gene. The BTK gene provides instructions for making an enzyme that is critical for the development of B cells, which are important for the immune system. Since this condition is inherited in an X-linked pattern, it primarily affects males.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about research is currently limited for this condition.