T-B- severe combined immunodeficiency

T-B- severe combined immunodeficiency (SCID) is a group of rare immune system disorders that affects the body’s ability to fight infections. This condition is characterized by a lack of functional T and B lymphocytes, which are white blood cells essential for the immune response. As a result, people with this condition often experience severe, recurrent respiratory, viral, bacterial, or fungal infections early in life. In some sub-types of this condition, there is also an increased sensitivity to ionizing radiation. This overview is based on trusted information that highlights the genetic nature of the disorder along with its marked impact on the immune system.

Common signs of T-B- SCID include early-onset severe infections such as respiratory infections, viral infections, bacterial and fungal infections, and persistent diarrhea. These recurrent infections, along with failure to thrive (difficulty in growing and developing properly), are key symptoms that can be seen in people with this condition.

T-B- SCID is a monogenic disorder, which means it is caused by changes in a single gene that lead to the malfunctioning or absence of certain immune cells. This genetic issue affects the creation and function of peripheral T and B cells, compromising the immune system. Information about specific genes involved is not available from the provided sources.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about research is currently limited for this condition.