malignant hyperthermia of anesthesia

Malignant hyperthermia of anesthesia is a pharmacogenetic disorder of skeletal muscle that can cause a dangerous and rapid increase in metabolism when certain anesthetic gases are used. This condition is most often triggered by potent volatile anesthetics such as halothane, sevoflurane, and desflurane, or by the muscle relaxant succinylcholine. It can, in rare cases, also be triggered by stresses like vigorous exercise or heat. Because the condition involves an abnormal reaction in skeletal muscle, it is important to recognize that it is linked to a genetic predisposition. People with this condition can experience a hypermetabolic state during exposure to these agents, which is why awareness and proper management during anesthesia are critical.

Information about symptoms is currently limited for this condition.

Malignant hyperthermia of anesthesia is described as a pharmacogenetic disorder, which means that a genetic predisposition makes certain people susceptible to a hypermetabolic reaction when exposed to specific anesthetic agents. The triggers include potent volatile anesthetics and succinylcholine, with rare cases occurring due to external stresses like vigorous exercise or heat. There is limited detailed information about the specific genetic mutations involved.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research and future directions is currently limited for this condition.