hereditary spastic paraplegia

Hereditary spastic paraplegia (HSP) is a group of neurodegenerative disorders that are both genetically and clinically diverse. People with this condition experience gradual stiffness and increased reflexes in their lower limbs, which can make walking and balancing more difficult over time. The condition has been known by various names, including spastic paraplegia, familial spastic paraplegia, and several others. Because it is caused by inherited changes, HSP can vary widely from one family to another. The information provided here is based on a basic definition of the condition and highlights its key characteristics.

Common symptoms of hereditary spastic paraplegia include progressive spasticity (muscle stiffness) and hyperreflexia (increased reflex reactions) in the lower limbs. Since HSP is clinically diverse, the symptoms can range in severity and presentation among different people.

Hereditary spastic paraplegia is caused by inherited changes in genes. It is a genetically heterogeneous disorder, meaning that changes in different genes can lead to the condition. Specific gene details are not provided in the information available.

Information about treatment is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about research is currently limited for this condition.