Clark-Baraitser syndrome

Clark-Baraitser syndrome is a rare condition that is linked to neurodevelopmental challenges. Although a full definition is not available, the condition is known by several names, which hint at its main features. Some of these names include MRD49 and autosomal dominant intellectual disability 49, suggesting that intellectual disability is a key aspect. In addition, descriptions associated with the condition mention physical characteristics such as tall stature, obesity, macrocephaly (larger head size), and unique facial features. Research has indicated that changes in the TRIP12 gene may play a role in the development of this syndrome. Overall, while detailed information is limited, these features provide a general picture of Clark-Baraitser syndrome.

People with Clark-Baraitser syndrome may experience challenges with intellectual and developmental skills. Descriptions of the condition also note some physical features that can include tall stature, obesity, a larger head (macrocephaly), and characteristic facial features. It is important to note that not all individuals may exhibit all of these features.

The cause of Clark-Baraitser syndrome is linked to changes in the TRIP12 gene. The condition is described in some sources as being autosomal dominant, meaning that a change in just one copy of the gene may be enough to cause the condition.

Information about treatment options and management approaches is currently limited for this condition.

Information about prognosis and quality of life considerations is currently limited for this condition.

Information about current research and future directions is currently limited for this condition.