SMARCB1-deficient kidney medullary carcinoma

SMARCB1-deficient kidney medullary carcinoma is a high-grade cancer that starts in the inner part of the kidney known as the renal medulla. This cancer is marked by a change in the SMARCB1 gene, leading to its inactivation. It can affect both children and adults and is mainly seen in patients with sickle cell trait, with most cases occurring in the right kidney. Because this cancer is aggressive and develops in a sensitive part of the kidney, it can be challenging to diagnose early. Researchers and clinicians are studying it to better understand its behavior and improve care. Information about symptoms, diagnosis, treatment, and long-term outcomes is still evolving.

Information about symptoms is currently limited for this condition.

The development of SMARCB1-deficient kidney medullary carcinoma is linked to the inactivation of the SMARCB1 gene. Additionally, having sickle cell trait is noted as a risk factor for this type of cancer. More research is needed to fully understand the causes and factors contributing to its development.

Information about treatment options is currently limited for this condition.

Information about prognosis is currently limited for this condition.

Information about current research and future directions is currently limited for this condition.